Studies show Tylenol can affect our mental pain as well as our physical.

Daniel Randles and colleagues at the University of British Columbia write in the journal Psychological Science, "The meaning-maintenance model posits that any violation of expectations leads to an affective experience that motivates compensatory affirmation. We explore whether the neural mechanism that responds to meaning threats can be inhibited by acetaminophen." Totally.

More plainly, "Physical pain and social rejection share a neural process and subjective component that are experienced as distress." That neural process has been traced to the same part of the brain. They figure that if you blunt one, you blunt both. As they told LiveScience, "When people feel overwhelmed with uncertainty in life or distressed by a lack of purpose, what they’re feeling may actually be painful distress … We think that Tylenol is blocking existential unease in the same way it prevents pain, because a similar neurological process is responsible for both types of distress."

via Paul Ford